Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5889123 | Bone | 2016 | 8 Pages |
Abstract
In the present study we show for the first time that the absence of nitric oxide synthases results in a disturbed arginine-NO metabolism and inadequate fracture healing with the transition of delayed union into a nonunion in mice after a femur osteotomy. Based on these data we suggest that the arginine-NO metabolism may play a role in the prevention of delayed unions and nonunions.
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Authors
D.M. Meesters, S. Neubert, K.A.P. Wijnands, F.L. Heyer, S. Zeiter, K. Ito, P.R.G. Brink, M. Poeze,