Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5890218 | Bone | 2014 | 11 Pages |
Abstract
A single dose of zoledronic acid caused significant changes in the bone area suggested to contain the metastatic niche. Tumour cells arriving in this modified bone microenvironment appeared to preferentially locate to osteoblast-rich areas, supporting that osteoblasts may be key components of the bone metastasis niche and therefore a potential therapeutic target in breast cancer.
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Authors
Marie-Therese Haider, Ingunn Holen, T. Neil Dear, Keith Hunter, Hannah K. Brown,