Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5890304 | Bone | 2014 | 14 Pages |
Abstract
These findings demonstrate that Alplâ/â mice exhibit a craniofacial skeletal phenotype similar to that seen in infants with HPP, including true bony craniosynostosis in the context of severely diminished bone mineralization. Future studies will be required to determine if TNAP deficiency and other forms of rickets promote craniosynostosis directly through abnormal calvarial cell behavior, or indirectly due to deficient growth of the cranial base.
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Authors
Jin Liu, Hwa Kyung Nam, Cassie Campbell, Kellen Cristina da Silva Gasque, José Luis Millán, Nan E. Hatch,