Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5890579 | Bone | 2013 | 12 Pages |
Abstract
The T-allele of rs1861809 SNP in the TRPV4 locus was associated with a 30% increased risk (95% CI: 1.1-1.6; p = 0.013) for non-vertebral fracture risk in men, but not in women, in the Rotterdam Study. Meta-analyses with the population-based LASA study confirmed the association with non-vertebral fractures in men. This was lost when the non-population-based studies Mr. OS and UFO were included. In conclusion, TRPV4 is a male-specific regulator of bone metabolism, a determinant of bone strength, and a potential risk predictor for fractures through regulation of bone matrix mineralization and intra-cortical porosity. This identifies TRPV4 as a unique sexually dimorphic therapeutic and/or diagnostic candidate for osteoporosis.
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Authors
B.C.J. van der Eerden, L. Oei, P. Roschger, N. Fratzl-Zelman, J.G.J. Hoenderop, N.M. van Schoor, U. Pettersson-Kymmer, M. Schreuders-Koedam, A.G. Uitterlinden, A. Hofman, M. Suzuki, K. Klaushofer, C. Ohlsson, P.J.A. Lips, F. Rivadeneira, R.J.M. Bindels,