Article ID Journal Published Year Pages File Type
5890621 Bone 2013 7 Pages PDF
Abstract
►We examined preventive effects of anti-vasospasm agent on the development of steroid-induced osteonecrosis in rabbits. ►The anti-vasospasm agent (fasudil) prevented the development of osteonecrosis. ►The endothelinA-receptor expressions were decreased in the fasudil group. ►The eNOS expression levels in both serum and bone marrow were decreased in the steroid alone group. ►Vasospasm plays an important role on the development of steroid-induced osteonecrosis.
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Life Sciences Biochemistry, Genetics and Molecular Biology Developmental Biology
Preview
Preventive effects of the anti-vasospasm agent via the regulation of the Rho-kinase pathway on the development of steroid-induced osteonecrosis in rabbits
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