Article ID Journal Published Year Pages File Type
5890622 Bone 2013 10 Pages PDF
Abstract
► Osteoporosis and osteoarthritis are major health problems in the elderly population, particularly in postmenopausal women, but their relationship remains unclear. ► Early ALN treatment completely prevented both subchondral bone loss and cartilage surface erosion caused by OVX. ► Late ALN treatment inhibited subchondral bone loss and significantly reduced cartilage erosion, although they did not recover to normal levels. ► Treatment for OP with bone resorption inhibitors reduces cartilage degeneration when menopause-related OP and OA coexist in same individuals.
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