Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5890663 | Bone | 2013 | 12 Pages |
Abstract
⺠Using an enzymatic digestion approach, we separately isolated endosteal and central bone marrow from rodent long bones. ⺠The endosteal bone marrow contained a much higher number of mesenchymal progenitors than the central bone marrow. ⺠Endosteal mesenchymal progenitors are able to undergo multi-lineage differentiation and express mesenchymal stem cell surface markers. ⺠Endosteal mesenchymal progenitors are more proliferative, immunosuppressive, and responsive to aging and parathyroid hormone than central mesenchymal progenitors. ⺠Therefore, they represent a distinct population of mesenchymal progenitors that are more metabolically active and relevant to physiological bone formation.
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Authors
Valerie A. Siclari, Ji Zhu, Kentaro Akiyama, Fei Liu, Xianrong Zhang, Abhishek Chandra, Hyun-Duck Nah, Songtao Shi, Ling Qin,