Article ID Journal Published Year Pages File Type
5890663 Bone 2013 12 Pages PDF
Abstract
► Using an enzymatic digestion approach, we separately isolated endosteal and central bone marrow from rodent long bones. ► The endosteal bone marrow contained a much higher number of mesenchymal progenitors than the central bone marrow. ► Endosteal mesenchymal progenitors are able to undergo multi-lineage differentiation and express mesenchymal stem cell surface markers. ► Endosteal mesenchymal progenitors are more proliferative, immunosuppressive, and responsive to aging and parathyroid hormone than central mesenchymal progenitors. ► Therefore, they represent a distinct population of mesenchymal progenitors that are more metabolically active and relevant to physiological bone formation.
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