| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5890760 | Bone | 2012 | 12 Pages |
Abstract
⺠We examine the expression of P2 receptors by osteoblasts. ⺠We look at the effects of extracellular nucleotides on osteoblast function. ⺠P2X receptor agonists inhibit bone mineralisation and ALP activity. ⺠P2X receptor agonists increase E-NPP1 activity. ⺠These effects are mediated via the P2X1 and P2X7 receptor subtypes.
Keywords
PPIUDPNMPUTPADPBz-ATPE-NTPDaseα,β-methylene adenosine 5′-triphosphateNTPNDPNucleotide monophosphateuridine diphosphateα,β-MeATPAdenosine TriphosphateATPadenosine diphosphateALPAlkaline phosphataseOsteoblastsUridine triphosphateecto-nucleoside triphosphate diphosphohydrolasenucleotide triphosphatenucleotide diphosphatePhosphatelactate dehydrogenaseLDHMineralisationPyrophosphateP2X receptors
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Authors
Isabel R. Orriss, Michelle L. Key, Andrea Brandao-Burch, Jessal J. Patel, Geoffrey Burnstock, Timothy R. Arnett,