Article ID Journal Published Year Pages File Type
5890791 Bone 2012 9 Pages PDF
Abstract
► We investigated, for the first time, the associations of estrogen with adiponectin in osteoblastic OPG and RANKL expression. ► We revealed that E2 blocked the activation of adiponectin-induced p38 MAPK. ► We revealed that E2 suppressed the adiponectin-regulated OPG and RANKL expression. ► E2 attenuated both the decrease of OPG and increase of RANKL expression regulated by adiponectin with time.
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