Hypophosphatemic rickets is associated with disruption of mineral orientation at the nanoscale in the flat scapula bones of rachitic mice with development

► During murine scapulae development, mineral nanoplatelet alignment and content increase faster in the periphery compared to the intermediate region. ► In the rachitic condition, nanoscale mineral orientation and direction are altered together with altered muscle forces and reduced mineralisation. ► Nanostructural mineral parameters may mediate fracture and deformability in rickets via association between muscle forces and mineral alignment.