Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5891081 | Bone | 2013 | 7 Pages |
Abstract
⺠Determinants of bone mass in Tanner stage I, and associations of biochemical markers with bone densitometric values were investigated. ⺠Estradiol levels play a key role in defining bone turnover and bone mass in both genders already in prepuberty. ⺠Estradiol negatively correlates with 25(OH)D. In girls only, osteocalcin positively correlates with estradiol and PTHi when 25(OH)D is low. ⺠Elevated PTHi levels should be evaluated with caution, because the cut-off in Tanner stage I is not well established. ⺠Low 25(OH)D levels may not necessarily reflect a negative biochemical milieu, but rather increased estradiol supporting bone formation.
Keywords
DXAtBMDlumbar spine bone mineral densityLBMDquartilesBMDS25-Hydroxy vitamin D3TALPprepubertyBMCsP1NPOPGFGF23phosDBPRANKLBMDTSHIOM25(OH)D3OsteoprotegerinEstradiolstandard deviationBone mineral densityBone massdual-energy X-ray absorptiometrybody mass indexBMIfibroblast growth factor 23Inorganic phosphorusReference rangeMagnesiumInstitute of Medicinefollicle-stimulating hormoneluteinizing hormoneFSHparathyroid hormoneCalcium
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Authors
Violetta Csakvary, Tamas Puskas, Gyorgy Oroszlan, Peter Lakatos, Bernadette Kalman, Gabor L. Kovacs, Erzsebet Toldy,