Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5891097 | Bone | 2013 | 4 Pages |
Abstract
This paper reports a proof of principle of direct depiction of trabecular bone microstructure in vitro by means of magnetic resonance imaging (MRI). Such depiction is achieved by 1H imaging of water embedded in the bone matrix. The fast transverse relaxation of this compartment with T2â on the order of a few hundreds of microseconds is addressed by a three-dimensional MRI technique with zero echo time (ZTE). ZTE imaging at an isotropic spatial resolution of 56 μm is demonstrated in a trabecular bone specimen extracted from a bovine bone. In the MR images, the trabecular bone structure is clearly depicted and a high level of robustness against off-resonance artefacts is observed. The structural accuracy of the MR data is investigated by comparison with x-ray micro-computed tomography.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Developmental Biology
Authors
Markus Weiger, Marco Stampanoni, Klaas P. Pruessmann,