Failure to generate bone marrow adipocytes does not protect mice from ovariectomy-induced osteopenia

► Compared to WT mice, kit receptor-deficient kitW/W-v mice had lower body fat and lacked bone marrow adipocytes. ► Adipocytes were present in bone marrow of WT mice and bone marrow adiposity increased following ovariectomy. ► Adipocytes were not detected in ovariectomized kitW/W-v mice. ► Significant differences in bone response to ovariectomy were not detected between WT and kitW/W-v mice. ► Our findings do not support a causal role for increased marrow fat as a mediator of ovariectomy-induced osteopenia in mice.