| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5891347 | Bone | 2013 | 12 Pages |
Abstract
⺠Wnt/β-catenin signaling is active in osteoblast or osteoblast precursor cell lines, including MC3T3-E1, 2T3, C2C12, and C3H10T1/2 cells. ⺠The BMP and Wnt/β-catenin signaling pathways cooperatively regulate osteoblast differentiation and bone formation. ⺠The Wnt//β-catenin pathway is an upstream activator of BMP2 expression, and blocking this pathway decreased BMP2 expression in osteoblasts. ⺠β-Catenin/TCF4 directly transactivates BMP2 transcription through specific Tcf/Lef binding elements in the BMP2 promoter.
Keywords
GSK3lymphoid enhancer binding factorDickkopf-related protein 1TGF-βOSE2β-TrCPSfrp4COL1A1SBEDKK1pTHWntCREBPGE2ICATCTGFNF-κBGAPDHRT-PCRH&ELRP5/6Wnt/β-CateninALPAlkaline phosphataseOsteogenesisGene expressionTransforming Growth Factor BetaTRESmad binding elementnuclear factor κBLefBMPHematoxylin and Eosinparathyroid hormonereverse transcription polymerase chain reactioncAMP responsive element binding proteinβ-transducin repeat-containing proteinBone morphogenetic proteinSecreted frizzled-related protein 4Prostaglandin E2glyceraldehyde 3-phosphate dehydrogenaseglycogen synthase kinase 3
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Authors
Rongrong Zhang, Babatunde O. Oyajobi, Stephen E. Harris, Di Chen, Christopher Tsao, Hong-Wen Deng, Ming Zhao,