| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5891393 | Bone | 2013 | 12 Pages |
Abstract
⺠Deleting Hdac3 in mature osteoblasts with Osteocalcin-Cre (Hdac3 CKOOCN) caused progressive cortical and trabecular bone loss with age. ⺠Cortical bone mineralization and material properties were compromised in Hdac3 CKOOCN as compared to control mice. ⺠Bone loss in Hdac3 CKOOCN mice was attributed to decreased bone formation and osteoblast/osteocyte function. ⺠Hdac3 deletion caused DNA damage in osteoblasts and osteocytes in vitro and in vivo. ⺠Chondrocyte activity and growth plate development were not affected in Hdac3 CKOOCN mice.
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Authors
Meghan E. McGee-Lawrence, Elizabeth W. Bradley, Amel Dudakovic, Samuel W. Carlson, Zachary C. Ryan, Rajiv Kumar, Mahrokh Dadsetan, Michael J. Yaszemski, Qingshan Chen, Kai-Nan An, Jennifer J. Westendorf,