Coordinated time-dependent modulation of AMPK/Akt/mTOR signaling and autophagy controls osteogenic differentiation of human mesenchymal stem cells

Article ID	Journal	Published Year	Pages	File Type
5891464	Bone	2013	8 Pages	PDF

Abstract

âº We tested the role of AMPK in osteoblast differentiation of mesenchymal stem cells âº AMPK caused early mTOR inhibition-dependent autophagy in differentiating human MSC âº AMPK caused late activation of Akt in differentiating MSC âº AMPK-induced autophagy and Akt activity contributed to osteoblast differentiation

Keywords

AMPK LC3 BMP2 bone morphogenetic protein 2 adenosine monophosphate-activated protein kinase

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Developmental Biology

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Coordinated time-dependent modulation of AMPK/Akt/mTOR signaling and autophagy controls osteogenic differentiation of human mesenchymal stem cells

Authors

Aleksandar Pantovic, Aleksandra Krstic, Kristina Janjetovic, Jelena Kocic, Ljubica Harhaji-Trajkovic, Diana Bugarski, Vladimir Trajkovic,