| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5891489 | Bone | 2012 | 13 Pages |
Abstract
⺠Overexpression of Wnt6, Wnt10a or Wnt10b blocks adipogenesis and stimulates osteoblastogenesis. ⺠Stable knockdown of these Wnts enhances adipogenesis and impairs osteoblastogenesis. ⺠β-Catenin is required for effects of these Wnts on fate of mesenchymal precursors.
Keywords
Id2CCAAT/enhancer-binding protein-αTle3Inhibitor of DNA binding 2FZDGSK3FABP4BATLRPPPARγTCFMSCC/EBPαAdipogenesisOsteoblastogenesisWAT, White adipose tissuebrown adipose tissueβ-cateninMesenchymal stem cellWnt signalingT-cell factorFatty acid-binding protein 4low density lipoprotein receptor-related proteinWATglycogen synthase kinase-3frizzled receptorPeroxisome proliferator-activated receptor-γ
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Developmental Biology
Authors
William P. Cawthorn, Adam J. Bree, Yao Yao, Baowen Du, Nahid Hemati, Gabriel Martinez-Santibañez, Ormond A. MacDougald,