Article ID Journal Published Year Pages File Type
5891525 Bone 2011 10 Pages PDF
Abstract
► Sclerostin expression enhanced by BMPs and coupled to osteoblast mineralization. ► BMPs, Wnt3a and PTH do not directly activate sclerostin promoter. ► BMP2 increases expression of several sclerostin inhibitors. ► MEF2B increased activity of the promoter and ECR5 element. ► No ECR5 enhancer activity in human osteosarcoma cells.
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