Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK

Article ID	Journal	Published Year	Pages	File Type
5891528	Bone	2011	8 Pages	PDF

Abstract

âº Zinc-deficiency decreased osteoblasts and osteoclasts in the proximal tibia of rat. âº These decreases were associated with reduced osteoblastogenesis and osteoclastogenesis. âº The reduced osteoblastogenesis was associated with the decreased expression of Runx2. âº The reduced osteoclastogenesis was associated with the decreased expression of RANK. âº Zinc-deficiency decreased SP-1 and MITF protein in bone.

Keywords

GSK3β CFU-M C-terminal telopeptide of type I collagen Sost LRP5 Dlx5 IGF-IR osterix Col1α1 DKK1 INSR IGF-I TRAP TBARS CTx-1 Sclerosteosis GSH RUNX2 RANKL Wnt/β-catenin pathway ALP Alkaline phosphatase Osteoblastogenesis Osteoclastogenesis tartrate-resistant acid phosphatase insulin-like growth factor I Osx Rank Dickkopf 1 Runt-related transcription factor 2 BMP thiobarbituric acid-reactive substances Low-density lipoprotein receptor-related protein 5 Bone morphogenetic protein Zinc-deficiency Glutathione Glycogen synthase kinase 3β IGF-I receptor insulin receptor