| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5891547 | Bone | 2011 | 13 Pages |
Abstract
⺠This review explains first the different genetic strategies used to study gene function in vivo. ⺠The generation of loss and gain of function mouse models is explained, emphasizing advantages and limitations of such approaches. ⺠The most popular promoters used to achieve cell specificity in bone cells and in conditional knock-out models are described. ⺠A list of the main cre transgenic lines is provided. ⺠Precautions to be taken during the phenotypic analysis of these genetic models are given.
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Authors
Florent Elefteriou, Xiangli Yang,