| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5891550 | Bone | 2011 | 9 Pages |
Abstract
⺠Cannabinoid receptor 1 (CB1) mediates the deleterious effects of glucocorticoid on MC3T3-E1 osteoblastic cell survival and differentiation. ⺠ERK and GSK-3β signaling transduction contributes to CB1 regulation of osteoblastic activities. ⺠The osteogenic transcription factor Runx2 reciprocally regulates CB1 signaling in glucocorticoid-stressed osteoblastic cells. ⺠CB1 blockade is an alternative strategy for alleviating the adverse actions of glucocorticoid on osteoblastic activities.
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Authors
Re-Wen Wu, Tzu-Ping Lin, Jih-Yang Ko, Da-Wei Yeh, Ming-Wen Chen, Huei-Ching Ke, Shin-Long Wu, Feng-Sheng Wang,