| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5891699 | Bone | 2011 | 13 Pages |
Abstract
⺠The cathepsin K inhibitor odanacatib inhibits bone resorption without affecting osteoclastogenesis, survival, migration or activation (polarization). ⺠Odanacatib decreases overall osteoclast resorption efficiency by inhibiting collagen degradation in the resorption lacunae and disrupting transcytosis. ⺠Odanacatib treatment leads to significant retention of intracellular vesicles containing cathepsin K, TRAP and bone matrix proteins.
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Authors
P. Leung, M. Pickarski, Y. Zhuo, P.J. Masarachia, L.T. Duong,