Article ID Journal Published Year Pages File Type
5891803 Bone 2011 8 Pages PDF
Abstract
► Specific knockout of Stat3 in osteoblast/ostecyte leads to a lower bone mass and mechanical properties. ► Stat3 deficiency suppresses loading induced bone formation. ► Stat3 deficiency inhibits mitochondrial function and causes Reactive Oxidative Species (ROS) accumulation in calvarial osteoblasts. ► Fluid shear stress may enhance mitochondrial function, but fails to do so in Stat3 deficient calvarial osteoblasts.
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