Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5891803 | Bone | 2011 | 8 Pages |
Abstract
⺠Specific knockout of Stat3 in osteoblast/ostecyte leads to a lower bone mass and mechanical properties. ⺠Stat3 deficiency suppresses loading induced bone formation. ⺠Stat3 deficiency inhibits mitochondrial function and causes Reactive Oxidative Species (ROS) accumulation in calvarial osteoblasts. ⺠Fluid shear stress may enhance mitochondrial function, but fails to do so in Stat3 deficient calvarial osteoblasts.
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Authors
Hongkang Zhou, America B. Newnum, Joseph R. Martin, Ping Li, Mark T. Nelson, Akira Moh, Xin-Yuan Fu, Hiroki Yokota, Jiliang Li,