Article ID Journal Published Year Pages File Type
5891886 Bone 2012 7 Pages PDF
Abstract
► Osteocyte apoptosis promotes osteoclast precursor adhesion to endothelial cells. ► Osteocyte apoptosis induces increased ICAM-1 expression in endothelial cells. ► Blocking ICAM-1 abolishes apoptosis-induced osteoclast precursor adhesion. ► Apoptotic osteocyte culture contains more IL-6 and sIL-6R than non-apoptotic culture. ► Both IL-6 and sIL-6R are required for endothelial activation.
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Life Sciences Biochemistry, Genetics and Molecular Biology Developmental Biology
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Osteocyte apoptosis regulates osteoclast precursor adhesion via osteocytic IL-6 secretion and endothelial ICAM-1 expression
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