Article ID Journal Published Year Pages File Type
5891981 Bone 2011 11 Pages PDF
Abstract
► Denosumab markedly reduced cortical and trabecular bone remodeling in OVX cynos. ► Denosumab reduced trabecular eroded surfaces and cortical porosity. ► Lowest levels of remodeling at each site were associated with greatest structural strength. ► Cortical remodeling parameters had little or no relationship with cortical material properties. ► Denosumab effects on remodeling were fully reversible upon clearance of drug.
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