Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5891981 | Bone | 2011 | 11 Pages |
Abstract
⺠Denosumab markedly reduced cortical and trabecular bone remodeling in OVX cynos. ⺠Denosumab reduced trabecular eroded surfaces and cortical porosity. ⺠Lowest levels of remodeling at each site were associated with greatest structural strength. ⺠Cortical remodeling parameters had little or no relationship with cortical material properties. ⺠Denosumab effects on remodeling were fully reversible upon clearance of drug.
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Authors
Paul J. Kostenuik, Susan Y. Smith, Jacquelin Jolette, Joseph Schroeder, Ian Pyrah, Michael S. Ominsky,