| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5891996 | Bone | 2011 | 9 Pages |
Abstract
⺠ATF936, a novel calcilytic, functions as an efficacious PTH- secretagogue. ⺠It triggers transient elevations of endogenous PTH in rats and in dogs, and is moderately bone anabolic in rats. ⺠In humans, transient releases of PTH show an exposure profile close to that observed after s.c. teriparatide. ⺠Translational data constitute a proof-of-concept for this chemical class of calcilytics.
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Authors
Markus R. John, Leo Widler, Rainer Gamse, Thomas Buhl, Klaus Seuwen, Werner Breitenstein, Gerard J.M. Bruin, Rossella Belleli, Lloyd B. Klickstein, Michaela Kneissel,