| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5892001 | Bone | 2011 | 7 Pages |
Abstract
⺠We find a positive correlation between ENB-0040 dose and prevention of mineralization defects in a murine model of hypophosphatasia. ⺠We find a positive relationship between ENB-0040 dose and survival. ⺠Urinary pyrophosphate is not a good follow up marker for evaluating response when using bone-targeted TNSALP treatment. ⺠These studies help set the therapeutic range of ENB-0040 to be chosen for clinical trials.
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Authors
Manisha C. Yadav, Isabelle Lemire, Pierre Leonard, Guy Boileau, Laurent Blond, Martin Beliveau, Esther Cory, Robert L. Sah, Michael P. Whyte, Philippe Crine, José Luis Millán,