| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5892006 | Bone | 2011 | 11 Pages |
Abstract
⺠An osteoclast progenitor cell-based high-throughput screening system was designed. ⺠Orphan ligand library screening identified harmine to be an NFAT-targeting molecule. ⺠Harmine activated NFATc1 expression by interfering with DYRK1A in preosteoclasts. ⺠Harmine induced Id2 expression leading to dominant inhibition of cell-cell fusion.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Developmental Biology
Authors
Hiroshi Egusa, Masanori Doi, Makio Saeki, Sho Fukuyasu, Yoshihiro Akashi, Yoshifumi Yokota, Hirofumi Yatani, Yoshinori Kamisaki,