| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5892028 | Bone | 2011 | 18 Pages |
Abstract
⺠The biological effects of bisphosphonates (BPs) were first published in 1969. ⺠The potency of BPs on bone resorption depends on binding to bone mineral and osteoclast inhibition. ⺠Nitrogen-BPs inhibit farnesyl pyrophosphate synthase(FPPS) and protein prenylation. ⺠BPs are the major drugs for treating Paget's disease, bone metastases, and osteoporosis. ⺠Knowledge of structure-activity enables rational design of new BP drugs.
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Authors
R. Graham G. Russell,