The primary site of the acrocephalic feature in Apert syndrome is a dwarf cranial base with accelerated chondrocytic differentiation due to aberrant activation of the FGFR2 signaling

Article ID	Journal	Published Year	Pages	File Type
5892103	Bone	2011	10 Pages	PDF

Abstract

âº Expression of Apert-type mutant Fgfr2IIIc in chondrocytes reproduced acrocephaly. âº Upregulation of p21, Ihh, Mmp-13 indicated acceleration of endochondral ossification. âº The acrocephalic feature is not alone a result of the coronal synostosis. âº It is primarily due to the precocious endochondral ossification in the cranial base.

Keywords

Spheno-occipital synchondrosis LMD SOS laser microdissection Apert syndrome quantitative real time polymerase chain reaction

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Developmental Biology

Preview

The primary site of the acrocephalic feature in Apert syndrome is a dwarf cranial base with accelerated chondrocytic differentiation due to aberrant activation of the FGFR2 signaling

Authors

Masaki Nagata, Glen H. Nuckolls, Xibin Wang, Lillian Shum, Yukie Seki, Tomoyuki Kawase, Katsu Takahashi, Kazuaki Nonaka, Ichiro Takahashi, Arhab A. Noman, Kenji Suzuki, Harold C. Slavkin,