Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5892144 | Bone | 2009 | 6 Pages |
Abstract
The association of bone with the metabolic syndrome and its features, visceral fat accumulation or insulin resistance, remains unclear. We determined visceral and subcutaneous fat areas (V and S) by computed tomography on 187 men (28-83 years) and 125 postmenopausal women (46-82 years) with type 2 diabetes. Men whose V was 100 cm2 or more had significantly lower urinary N-terminal cross-linked telopeptide of type-I collagen (p = 0.005), higher femoral neck bone mineral density (FN-BMD) (p = 0.004), and lower prevalence of vertebral fractures (VFs) (p = 0.04) than controls. Fat mass, V, S, and lean body mass positively correlated with FN-BMD in men and with lumbar (L) and FN-BMD in women. When adjusted for weight, these correlations became negative. Urinary C-peptide positively correlated with FN-BMD in both genders. Multivariate logistic regression analysis adjusted for age, height, weight, L-BMD, duration of diabetes, and diabetes therapies identified V in men and urinary C-peptide in women as factors inversely associated with the presence of VFs [odds ratio (OR) = 0.61 per SD increase, p = 0.04, and OR = 0.32, p = 0.01, respectively]. These findings suggest that, of the components of the metabolic syndrome, body fat in gravity and hyperinsulinemia could increase FN-BMD in diabetic subjects. Visceral fat in men and hyperinsulinemia in women may protect against VFs independent of weight, L-BMD, diabetes duration, or therapies.
Keywords
DXAUrinary C-peptideTrunk fatT-CbaPWVTrunk fat mass%fatFPGIMTBMDBAPLBMDBPSBPOsteocalcinbone specific alkaline phosphataseVisceral fat accumulationBone mineral densitytriglycerideLean body masscomputed tomographyTotalDual x-ray absorptiometryType 2 diabetes mellitusBrachial-ankle pulse wave velocityThe metabolic syndromebody mass indexBMIRadialVertebral fracturesVertebral fractureIntima-media thicknessdiastolic blood pressuresystolic blood pressureFasting plasma glucoselumbarconfidential intervalvisceral fat areasubcutaneous fat areaodds ratioFatcreatininecholesteroltotal cholesterolFemoral neck
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Authors
Toru Yamaguchi, Ippei Kanazawa, Masahiro Yamamoto, Soichi Kurioka, Mika Yamauchi, Shozo Yano, Toshitsugu Sugimoto,