Quantification of bone tissue regeneration employing β-tricalcium phosphate by three-dimensional non-invasive synchrotron micro-tomography - A comparative examination with histomorphometry

Although the agreement between the 2-D methods is excellent in terms of computing the area fractions, the structural 3-D insight which can be derived from classical 2-D methods, including histomorphometric analysis is considerably limited. This fact is emphasized by the discrepancy between the measured areas and volume fractions.