Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5893091 | Current Opinion in Genetics & Development | 2015 | 6 Pages |
Abstract
Understanding the past is to understand the present. Mammalian life, with all its complexity comes from a humble beginning of a single fertilized egg cell. Achieving this requires an enormous diversification of cellular function, the majority of which is generated through a series of cellular decisions during embryogenesis. The first decisions are made as the embryo prepares for implantation, a process that will require specialization of extra-embryonic lineages while preserving an embryonic one. In this mini-review, we will focus on the mouse as a mammalian model and discuss recent advances in the decision making process of the early embryo.
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Authors
Chuen Yan Leung, Magdalena Zernicka-Goetz,