Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5893540 | Current Opinion in Genetics & Development | 2014 | 5 Pages |
Abstract
In the past few years, technological advances in nucleotide sequencing have culminated in a greater understanding of the complexity of the human transcriptome. Notably, the discovery that distal regulatory elements known as enhancers are transcribed and such enhancer-derived transcripts (eRNAs) serve a critical function in transcriptional activation has added a new dimension to transcriptional regulation. Here we review recent insights into the tissue-specific and temporal-specific gene regulation brought about by the discovery of eRNAs.
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Authors
Fan Lai, Ramin Shiekhattar,