| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5893748 | Current Opinion in Genetics & Development | 2012 | 6 Pages |
Abstract
The lin-4/miR-125 and let-7 microRNAs are at the heart of the heterochronic pathway, which controls temporal cell fate determination during Caenorhabditis elegans development. These small temporal RNAs are clustered along with a third microRNA, miR-100, in the genomes of most animals. Their conserved temporal and neural expression profile suggests a general role in cell fate determination during nervous system differentiation. By triggering consecutive differentiation programs, these microRNAs probably help to determine birth-order dependent temporal identity and thereby contribute to neural stem cell multipotency.
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Authors
Nicholas S Sokol,