Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5893857 | International Journal of Developmental Neuroscience | 2015 | 18 Pages |
Abstract
Considering that many teenagers and young adults commonly use ATS, our main aim was to review the neurotoxic effects of amphetamines, namely AMPH, MDMA, and METH, in the adolescence period of experimental animals. Reports agree that adolescent animals are less susceptible than adult animals to the neurotoxic effects of amphetamines. The susceptibility to the neurotoxic effects of ATS seems roughly located in the early adolescent period of animals. Many authors report that the age of exposure to ATS is crucial for the neurotoxic outcome, showing that the stage of brain maturity has a strong importance. Moreover, recent studies have been undertaken in young adults and/or consumers during adolescence that clearly indicate brain or behavioural damage, arguing for long-term neurotoxic effects in humans. There is an urgent need for more studies during the adolescence period, in order to unveil the mechanisms and the brain dysfunctions promoted by ATS.
Keywords
MDMA5-HTAMPHDOPAC5-HIAAp.o.5-HTTMAOVMATTphDATi.p.DOIs.c.norepinephrine transporterATSPNDGFAPUNODC1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane3,4-methylenedioxymethamphetamine5-hydroxytryptamine, serotonin5-Hydroxyindoleacetic acidPer osAmphetaminesAmphetamineattention deficit hyperactivity disorderDopamine transporterSPECTAdolescenceADHDfMRIfunctional magnetic resonance imagingsingle photon emission computed tomographyTUNELtyrosine hydroxylaseVesicular monoamine transporterNETintraperitonealCNSDopaminepostnatal daysubcutaneousHourserotonin transporterNeurotoxicitycentral nervous systemIntramuscularMETHMethamphetaminei.m.monoamine oxidasenorepinephrinehomovanillic acidtryptophan hydroxylaseGlial fibrillary acidic proteinHVA
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Authors
Armanda Teixeira-Gomes, Vera Marisa Costa, Rita Feio-Azevedo, Maria de Lourdes Bastos, Félix Carvalho, João Paulo Capela,