Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5893944 | International Journal of Developmental Neuroscience | 2013 | 6 Pages |
Abstract
The generation of new neurons from neural stem cells (NSCs) throughout adult life in the mammalian brain is a biological process that fascinates scientists for its uniqueness and restorative potential. In the dentate gyrus (DG) of the hippocampus NSCs are able to self-renew and generate new granule cells and astrocytes through a complex and plastic mechanism that can be regulated by endogenous and exogenous cues at different levels. Unexpected recent findings suggest that the population of NSCs is heterogeneous in morphology and behavior. We herein explore the hypothesis that NSC heterogeneity and the neurogenic potential of the DG depends on their developmental origin. We provide an up-to-date picture of the process of neurogenesis in the adult hippocampus with an especial focus on NSCs and outline key unsolved aspects. Further, we discuss the origin of NSCs in the adult DG from a developmental perspective and explore the possibility of NSC heterogeneity being determined from early postnatal periods and being responsible for the neurogenic output of the DG in the long term.
Keywords
RGCsGCLPSA-NCAMGLASTDcxNSCsBLBPGFPNeuroblastsANPGFAPpolysialic acid neural cell adhesion moleculeQNP5-bromo-2′-deoxyuridineBMPsECskainic acidBrdUdoublecortinDevelopmentAgingNeural stem cellselectroconvulsive shockdentate gyrusgranule cell layerNeurogenesisGlial fibrillary acidic proteingreen fluorescent proteinbone morphogenetic proteinsbrain lipid-binding protein
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Authors
Juan M. Encinas, Amanda Sierra, Roberto Valcárcel-MartÃn, Soraya MartÃn-Suárez,