Oligodendrogenesis from neural stem cells: Perspectives for remyelinating strategies

Article ID	Journal	Published Year	Pages	File Type
5893956	International Journal of Developmental Neuroscience	2013	9 Pages	PDF

Abstract

âº Spontaneous remyelination in MS fails with disease progression. âº Remyelination decline is multifactorial. âº Cell therapy may rely on NPCs transplantation or stimulation of local OPCs. âº Oligodendrogenesis may be a key target in cell therapy for MS. âº Ex vivo models of demyelination constitute an important tool toward MS cell therapy.

Keywords

inducible pluripotent stem cells TRS PLP IPSCs NGF EAE CNP cuprizone CNS repair CPZ MAG PDGFRα NSCs Embryonic neural stem cells eGFP SVZ MSCs MBP NPCs OPCs Proteolipid protein Remyelination experimental autoimmune encephalomyelitis Triiodothyronine CNS DIV days in vitro Cell therapy Mesenchymal stem cells Neural precursor cells Neural stem cells Oligodendrocyte precursor cells central nervous system peripheral nervous system dentate gyrus nerve growth factor subventricular zone Multiple sclerosis Myelin basic protein PNS Myelin-associated glycoprotein Platelet-derived growth factor receptor alpha oligodendrocytes