| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5893974 | International Journal of Developmental Neuroscience | 2011 | 9 Pages |
Abstract
ⶠAnimals exposed to gestational IV nicotine exhibited a generalized increase in startle responding compared to controls at PND 14. ⶠOn PND 18, animals preexposed to nicotine during gestation displayed hyperresponsive startle reflexes compared to controls with auditory, but not tactile, prepulse stimuli. ⶠWhen tested during adulthood, female rats prenatally exposed to nicotine showed a relative insensitivity to changes in the interstimulus interval (8-120 ms) compared to males exposed to nicotine. ⶠAn intermittent, low dose regime of IV nicotine during gestation produced long-term alterations in both preweanling and adult rats' acoustic startle responding.
Keywords
PPTgASRPNDPPIPreweanlingPNCnAChRsISISubstance use disorderadultSUDIntravenousgestational daypostnatal daySuperior colliculusInterstimulus intervalPrepulse inhibitionRatpedunculopontine tegmental nucleuscaudal pontine reticular nucleuscochlear nucleiacoustic startle responseInferior colliculusSensorimotor gatingnicotinic acetylcholine receptor
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Authors
Ryan T. Lacy, Charles F. Mactutus, Steven B. Harrod,