Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
58951 | Chinese Journal of Catalysis | 2015 | 6 Pages |
The one-pot eight-component reaction between Meldrum's acid, an aromatic aldehyde, and an aryl amine was achieved in the presence of citric acid catalyst. The corresponding dispirohydroquinolines were obtained in good yields with excellent diastereoselectivity. This method is a combination of the Knoevenagel and Michael reactions.
Graphical AbstractThe one-pot eight-component reaction between Meldrum's acid, an aromatic aldehyde and an arylamine was achieved in the presence of citric acid as the catalyst. The corresponding dispirohydroquinoline was obtained in good yield with excellent diastereoselectivity. This method is a combination of the Knoevenagel and Michael reactions.Figure optionsDownload full-size imageDownload as PowerPoint slide