| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5895147 | Placenta | 2014 | 7 Pages |
Abstract
Under cholestatic conditions placental 11βHSD2 mRNA is reduced. Studies in BeWo choriocarcinoma cells demonstrated that CDCA is likely to be the specific bile acid that mediates this effect. UDCA, the main bile acid used to treat cholestasis, did not reduce placental 11βHSD2 expression, further supporting its use in the management of ICP.
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Authors
M. Martineau, G. Papacleovoulou, S. Abu-Hayyeh, P.H. Dixon, H. Ji, R. Powrie, L. Larson, E.K. Chien, C. Williamson,