| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5895587 | Placenta | 2011 | 7 Pages |
Abstract
Increased PERK-pEIF2α and ATF6 signalling have been associated with decreased cellular proliferation and may contribute to the impaired placental growth characterising pregnancies with FGR and PE+FGR. XBP1(U) has been proposed as a negative regulator of ER stress, and increased levels in PE may reflect a protective mechanism against the detrimental effects of ER stress.
Keywords
Decidua basalisUPRIRE1XBP1ATF6eIF2αPKR-like ER kinaseinositol-requiring enzyme 1Endoplasmic reticulum stressGene expressionendoplasmic reticulumeukaryotic translation initiation factor 2αactivating transcription factor 6Fetal growth restrictionUnfolded protein responsepre-eclampsiaX-box binding protein 1PERK
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Authors
I.A. Lian, M. Løset, S.B. Mundal, M.H. Fenstad, M.P. Johnson, I.P. Eide, L. Bjørge, K.A. Freed, E.K. Moses, R. Austgulen,