Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5895847 | Placenta | 2012 | 4 Pages |
Abstract
Preeclampsia, a human pregnancy specific disorder is characterized by an anti-angiogenic state. As hydrogen sulfide (H2S) has pro-angiogenic and anti-oxidative characteristics, we hypothesized that H2S levels could play a role in the pathogenesis of preeclampsia and studied the placental expression of the H2S-producing enzymes cystathionine-γ-lyase (CSE) and cystathionine-β-synthase (CBS). CBS and CSE protein are expressed in the fetal-placental endothelium and CBS only in Hofbauer cells. CBS mRNA expression is decreased (p = 0.002) in early-onset preeclampsia, while CSE mRNA is unchanged. Thus, down regulation of CBS during early-onset preeclampsia may result in less H2S-production and may aid in the anti-angiogenic state.
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Authors
K.M. Holwerda, E.M. Bos, A. Rajakumar, C. Ris-Stalpers, M.G. van Pampus, A. Timmer, J.J.H.M. Erwich, M.M. Faas, H. van Goor, A.T. Lely,