Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5896478 | Best Practice & Research Clinical Endocrinology & Metabolism | 2015 | 15 Pages |
Abstract
Nuclear receptors belong to a superfamily of proteins that play central roles in human biology, orchestrating a large variety of biological functions in both health and disease. Understanding the interactions and regulatory pathways of NRs will allow development of potential therapeutic interventions for a multitude of disease processes. Non-coding RNAs have recently been discovered to have significant interactions with NR signalling pathways via a variety of biological connections. This review summarises the known interactions between ncRNAs and the NR superfamily in health, embryogenesis and a plethora of human diseases.
Keywords
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Biochemistry, Genetics and Molecular Biology
Endocrinology
Authors
Paul (Clinical Research Fellow and General Surgical Registrar), Walter (Lecturer in Medical Biochemistry), Silvia (Research Associate), Alex (Graduate Student), Jonathan (Consultant in Medical Oncology),