Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5896542 | Best Practice & Research Clinical Endocrinology & Metabolism | 2013 | 12 Pages |
Abstract
Thyroglobulin autoantibodies (TgAb) are detected at diagnosis or during treatment in approximately 25% of patients with differentiated thyroid cancer (DTC). When present, TgAb interferes with thyroglobulin (Tg) measurement causing falsely low or undetectable Tg immunometric assay (IMA) values that can mask disease. Guidelines mandate that every Tg test have TgAb measured simultaneously and quantitatively by immunoassay and not a recovery test. The propensity and magnitude of TgAb-Tg interference relates to both Tg and TgAb concentrations and the class of Tg method used. Because the TgAb trend reflects changes in thyroid tissue mass, TgAb concentrations serve as a surrogate post-operative DTC tumor marker. A rising, or de novo appearance of TgAb may indicate recurrence, whereas a progressive decline suggests successful treatment. This review focuses on the technical limitations of current TgAb methods, characteristics of TgAb interference with different classes of Tg method, and the clinical value of monitoring TgAb trends as a surrogate DTC tumor marker.
Keywords
Related Topics
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Biochemistry, Genetics and Molecular Biology
Endocrinology
Authors
Carole (Professor of Medicine, USC Keck School of Medicine, Technical Director USC Endocrine Laboratory), Shireen (Assistant Area Medical Director, Physician in Charge, Endocrinology, Southern California Permanente Medical Group, Panorama City,