Article ID Journal Published Year Pages File Type
5896552 Best Practice & Research Clinical Endocrinology & Metabolism 2011 9 Pages PDF
Abstract
► The GH and IGF-1 axis plays a pivotal role in critical illness. ► IGF-1 modulates hepatic acute phase response signal pathway. ► IGF-1 serum levels increase during critical illness and protease activity decreases. ► GH ameliorates hypermetabolism and catabolism, but mortality increase is associated. ► With adequate nutrition, anabolic therapy may still be appropriate in select groups.
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Life Sciences Biochemistry, Genetics and Molecular Biology Endocrinology
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