Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5896552 | Best Practice & Research Clinical Endocrinology & Metabolism | 2011 | 9 Pages |
Abstract
⺠The GH and IGF-1 axis plays a pivotal role in critical illness. ⺠IGF-1 modulates hepatic acute phase response signal pathway. ⺠IGF-1 serum levels increase during critical illness and protease activity decreases. ⺠GH ameliorates hypermetabolism and catabolism, but mortality increase is associated. ⺠With adequate nutrition, anabolic therapy may still be appropriate in select groups.
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Authors
Itoro E. (Postdoctoral Burn Research Fellow), Ludwik K. (Burns/Reconstruction Clinical Fellow), Celeste C. (Assistant Professor), David N. (Professor),