Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5896880 | Cytokine | 2015 | 7 Pages |
Abstract
We observed Th17 dominant environment in peripheral blood of patients in active state of disease, with “hyporesponsiveness”, in, in vitro stimulated PBMC-in their ability to secrete TNF-α and IL-6. Treg numbers were unaltered but function was compromised. Targeting PR3 specific effector memory cells, to prevent relapse, and instituting anti IL-17 therapy, or modulating Tregs could be newer forms of therapy for this serious autoimmune disease.
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Authors
Lekha Rani, Ranjana W. Minz, Aman Sharma, Shashi Anand, Dheeraj Gupta, N.K. Panda, V.K. Sakhuja,