| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5896984 | Cytokine | 2015 | 4 Pages |
â¢IL-18 contributes to susceptibility to L. amazonensis infection in C57BL/6 mice.â¢Macrophages do not contribute to these effects of IL-18.â¢BMMÏ do not express IL-18R constitutively or under any of the conditions studied.
We evaluated the role of IL-18 during Leishmania amazonensis infection in C57BL/6 mice, using IL-18KO mice. We showed that IL-18 is involved in susceptibility to L. amazonensis, since IL-18KO mice presented reduced lesions and parasite loads. Because macrophages are the host cells of the parasite, we investigated if macrophages were involved in IL-18-mediated susceptibility to L. amazonensis. We showed that macrophages obtained from WT or IL-18KO responded similarly to L. amazonensis infection. Moreover, we showed that C57BL/6 macrophages do not respond to IL-18, since they do not express IL-18R. Therefore, macrophages are not involved in IL-18-mediated susceptibility to L. amazonensis.
