| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5897234 | Cytokine | 2013 | 10 Pages |
Abstract
⺠Leptin (100 ng/mL) stimulates mitogenesis and raise T202/Y204P-ERK1/2 protein expression. ⺠Leptin impairs cell viability and muscle fiber formation. ⺠Both JAK/STAT3 and MEK/MAPK but not PI3-K/AKT/GSK-3β signaling pathways were activated by leptin. ⺠Insulin surpasses leptin effect through PI3-K/AKT-dependent inhibition of GSK-3beta. ⺠STAT3 (Y705P-STAT3) and MEK (T202/Y204P-ERK1/2) mediate leptin-dependent effects.
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Authors
Maja Pijet, Barbara Pijet, Anna Litwiniuk, Beata Pajak, Barbara Gajkowska, Arkadiusz Orzechowski,