Article ID Journal Published Year Pages File Type
5897267 Cytokine 2013 6 Pages PDF
Abstract
► APRIL induces HoxC4 and AID mRNA expression in mouse B cells. ► APRIL increases HoxC4 promoter activity in mouse B cells. ► Second NF-κB-binding element (NBE2) is essential for the HoxC4 promoter activation. ► APRIL enhances binding of NF-κB to the HoxC4 promoter NBE2 region. ► Overexpression of NF-κB increases APRIL-induced HoxC4 promoter activity.
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